Design Review Research Articles

Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings.

Children often show cognitive and affective traits that are similar to their parents. Although this indicates a transmission of phenotypes from parents to children, little is known about the neural underpinnings of that transmission. Here, we provide a general overview of neuroimaging studies that explore the similarity between parents and children in terms of brain structure and function. We notably discuss the aims, designs, and methods of these so-called intergenerational neuroimaging studies, focusing on two main designs: the parent-child design and the multigenerational design. For each design, we also summarize the major findings, identify the sources of variability between studies, and highlight some limitations and future directions. We argue that the lack of consensus in defining the parent-child transmission of brain structure and function leads to measurement heterogeneity, which is a challenge for future studies. Additionally, multigenerational studies often use measures of family resemblance to estimate the proportion of variance attributed to genetic versus environmental factors, though this estimate is likely inflated given the frequent lack of control for shared environment. Nonetheless, intergenerational neuroimaging studies may still have both clinical and theoretical relevance, not because they currently inform about the etiology of neuromarkers, but rather because they may help identify neuromarkers and test hypotheses about neuromarkers coming from more standard neuroimaging designs.

Recent Advances in High-Rate Solar-Driven Interfacial Evaporation.

Recent advances in solar-driven interfacial evaporation (SDIE) have led to high evaporation rates that open promising avenues for practical utilization in freshwater production and industrial application for pollutant and nutrient concentration, and resource recovery. Breakthroughs in overcoming the theoretical limitation of 2D interfacial evaporation have allowed for developing systems with high evaporation rates. This study presents a comprehensive review of various evaporator designs that have achieved pure evaporation rates beyond 4kgm-2h-1, including structural and material designs allowing for rapid evaporation, passive 3D designs, and systems coupled with alternative energy sources of wind and joule heating. The operational mechanisms for each design are outlined together with discussion on the current benefits and areas for improvement. The overarching challenges encountered by SDIE concerning the feasibility of direct integration into contemporary practical settings are assessed, and issues relating to sustaining elevated evaporation rates under diverse environmental conditions are addressed.

Cetin Dam – stabilising troubled abutment slopes

AbstractThe 420 MW Cetin Dam Project in Turkey was subject to severe setbacks, including substantial geotechnical problems. Since 2011, several concessionaires, contractors and designers were involved. In June 2016, a major failure occurred at a high cut slope of the right bank (RB) valley flank. In 2017, contractor Limak took over the project with a US$ 600 mio concession contract. To secure the contractual agreement for state‐guaranteed energy remuneration, Cetin Dam and hydro hydroelectric power plant (HEPP) had to be operative in 2020. Missing the time target would have implied high economic losses for the concessionaire, and this set‐in‐stone deadline imposed extraordinary pressure for developing fast and reliable solutions. Worryingly, progressing failure became evident at the failed RB cut slope, while rehabilitation works were ongoing. In late December 2017, shortly after a review of geotechnical conditions and slope design for the troubled RB slope had started, also parts of the left bank (LB) cut slope failed below crest level and threatened to grow into a global slope failure. With only 26 months’ time left for starting energy production, the slope instabilities jeopardised the economic success of the entire project. Within a 3‐month emergency mission for both RB and LB slopes, a dedicated team succeeded in understanding the geotechnical problems, planning and implementing immediate mitigation measures, and developing design solutions. Operation of Cetin Dam and HEPP commenced in 2020.

Online Course Design Review: Quality e-Learning Practices in Higher Education

This article presents the importance of online course revision to improve best practices in distance higher education, increase student success and raise retention rates. A year-long, systematic, unified approach to online course review was conducted by a committee of Humanities professors. The aim of this paper is to share the significant enhancements made to an online course design, using the 7th Edition of Quality Matters Higher Education Rubric to boost student engagement, performance, and satisfaction. This study discusses how each standard was applied to refine an online course. The purpose of the revision was to systematically address the standards as proposed by the QM rubric. Findings revealed areas to strengthen in each of the eight general standards resulting in the actualization of the course design to be more accessible and practical for student use. A few of the specific enhancements because of the revision were the creation of a course content map, clear and predictable design, weekly email reminders, and rubrics. Student feedback confirmed positive outcomes after the successful implementation of best practices using the QM rubric.

Text-based information design for in-vehicle displays: A systematic review

Reading short texts at a brief glance behaviour has been increasing, especially in the in-vehicle interface of the multitask context of driving. This behaviour led to a change in the approach of preparing and designing in-car information. Consequently, understanding the current status of existing design principles is necessary for designers to find the appropriate solution for text presentation on the in-vehicle display under driving conditions. Thus, the present study conducts a systematic review of text-based information design for in-vehicle displays. A total of 1,495 studies (1980–2022) were screened, and 360 emerged for full-text review; 27 studies met the inclusion criteria, including journal articles concerning the design of text-based information for in-vehicle displays involving text design and the effect on safe driving or reducing workload and distraction. The results were summarised in three themes of literature: existing design guidelines, design factors, and evaluation methodology. The existing guidelines and recommendations focus on the physical presence of text (modality, location, colour, typeface, font size), with few recommendations on the linguistic presence of the text (message style and message length). The discussion and future work section enables further work on developing usable and safe informational text displays on the in-vehicle interface and other short glance reading engagements.

Adult and pediatric relapsing multiple sclerosis phase II and phase III trial design and their primary end points: Asystematic review.

No systematic review of trial designs in patients with relapsing multiple sclerosis (RMS) was reported. This systematic review was conducted on the trial designs and primary end points (PEs) of phase II and III trials intended to modify the natural course of the disease in patients with RMS. The purpose of the study is to explore trends/topics and discussion points in clinical trial design and PE, comparing them to regulatory guidelines and expert recommendations. Three trial registration systems, ClinicalTrials.gov, the EU Clinical Trials Register, and the Japan Registry of Clinical Trials, were used and 60 trials were evaluated. The dominant clinical trial design was a randomized controlled parallel-arms trial and other details were as follows: in adult phase III confirmatory trials (n = 32), active-controlled double-blind trial (DBT) (53%) and active-controlled open-label assessor-masking trial (16%); in adult phase II dose-finding trials (n = 9), placebo- and active-controlled DBT (44%), placebo-controlled DBT (22%), and placebo-controlled add-on DBT (22%); and in pediatric phase III confirmatory trials (n = 8), active-controlled DBT (38%) and active-controlled open-label non-masking trial (25%). The most common PEs were as follows: in adult confirmatory trials, annual relapse rate (ARR) (56%) and no evidence of disease activity-3 (NEDA-3) (13%); in adult dose-finding trials, the cumulative number of T1 gadolinium-enhancing lesions (56%), combined unique active lesions (22%), and overall disability response score (22%); and in pediatric confirmatory trials, ARR (38%) and time to first relapse (25%). It was suggested that some parts of the regulatory guidelines and expert recommendations need to be revised.

Mechanical design of ITER radial neutron camera Ex-Port system

The Radial Neutron Camera is an ITER diagnostic designed to measure the un-collided 14 MeV and 2.5 MeV neutrons from deuterium-tritium (DT) and deuterium-deuterium (DD) fusion reactions, through an array of detectors covering a poloidal plasma section along collimated Lines Of Sight (LOS). It is composed by two fan-shaped collimating structures viewing the plasma radially through vertical slots in the diagnostic shielding module of ITER Equatorial Port 1: the In-Port RNC, devoted to plasma edge coverage, and the Ex-Port RNC, devoted to the plasma core coverage. This paper presents an overview of the mechanical design of the Ex-Port RNC at the Preliminary Design Review (PDR) stage. The Ex-Port RNC is located in the Port Interspace and consists of a massive shielding structure hosting the detector units and two sets of collimators lying on different toroidal planes. The Ex-Port RNC design is presented both from the point of view of functional requirements (e.g. LOS positions and angles, radiation shielding, weight limitations) and of manufacturability. Finally, the Ex-port RNC structural integrity is assessed, and its design validated against the main loads and load combinations.

From Conventional to Programmable Matter Systems: A Review of Design, Materials, and Technologies

Programmable matter represents a system of elements whose interactions can be programmed for a certain behavior to emerge (e.g., color, shape) upon suitable commands (e.g., instruction, stimuli) by altering its physical characteristics. Even though its appellation may refer to a morphable physical material, programmable matter has been represented through several approaches from different perspectives (e.g., robots, smart materials) that seek the same objective: controllable behavior such as smart shape alteration. Researchers, engineers, and artists have expressed interest in the development of smart modeling clay as a novel alternative to conventional matter and classical means of prototyping. Henceforth, users will be able to do/undo/redo forms based on computed data (CAD) or interactions (sensors), which will help them unlock more features and increase the usefulness of their products. However, with such a promising technology, many challenges need to be addressed, as programmable matter relies on energy consumption, data transmission, stimuli control, and shape formation mechanisms. Furthermore, numerous devices and technologies are created under the name of programmable matter, which may pose ambiguity to the control strategies. In this study, we determine the basic operations required to form a shape, then review different realizations using the shape shifting ability of programmable matter and their fitting classifications, and finally discuss potential challenges.

Evaluating supply chain performance measurement system (SCPMS) lifecycle during unexpected events

ABSTRACT Supply chain management is recognized as a crucial element in boosting organizational performance and competitiveness. However, the COVID-19 crisis has demonstrated that many corporations were unprepared and lacked a recovery strategy, which led to significant supply chain disruptions. Hence, the purpose of this study is to evaluate the Supply Chain Performance Measurement System (SCPMS) lifetime under unforeseen situations, particularly in developing nations like Egypt, and its relevance during the pandemic and post-pandemic periods. A systematic questionnaire was used to gather data from 100 manufacturing firms (supply chain and retailers) with large business volume who provided a total of 562 questionnaires. The findings indicated that there were four main measurement systems: SCPMS Design, SCPMS Implementation, SCPMS Use, and SCPMS Review. The results of the AHP method found that the SCPMS implementation was the most important system, while the least important was SCPMS design.

Impact of pharmaceutical care for asthma patients on health-related outcomes: An umbrella review.

Recent systematic reviews suggest that pharmacists' interventions in asthma patients have a positive impact on health-related outcomes. Nevertheless, the association is not well established, and the role of clinical pharmacists is poorly represented. The aim of this overview of systematic reviews is to identify published systematic reviews assessing the impact of pharmacists' interventions on health-related outcomes measured in asthma patients. PubMed, Embase, Scopus, and Cochrane Library were searched from inception to December 2022. Systematic reviews of all study designs and settings were included. Methodological quality was assessed using AMSTAR 2. Two investigators performed study selection, quality assessment and data collection independently. Nine systematic reviews met the inclusion criteria. Methodological quality was rated as high in one, low in two, and critically low in six. Reviews included 51 primary studies reporting mainly quality of life, asthma control, lung capacity, and therapeutic adherence. Only four studies were carried out in a hospital setting and only two reviews stated the inclusion of severe asthma patients. The quality of the systematic reviews was generally low, and this was the major limitation of this overview of systematic reviews. However, solid evidence supports that pharmaceutical care improves health-related outcomes in asthma patients.

A Systematic Review of Sustainable Supply Chain Network Design: Optimization Approaches and Research Trends

In response to the ever-increasing pursuit of competitiveness among organizations in today’s global business landscape, the subject of supply chain management has become a vital domain encompassing a wide range of sectors and industries across the economy. The growing concern about sustainable development has prompted public and private supply chain players to incorporate the three pillars of sustainability, namely, economic, environmental, and social, into the design of their supply chain networks. This study reviews and examines the content of 102 relevant papers to discuss the mathematical models, modeling approaches, and solutions that have been explored in the existing literature on forward sustainable supply chain network design. This paper also investigates the sustainability elements and supply chain network peculiarities including design factors and decision levels. In this review, several limitations in the current literature on sustainable supply chain network design optimization models are highlighted. According to the analysis, it was found that a better understanding of the industry and its sustainability requirements and priorities is essential for designing sustainable supply chain networks that are tailored to the needs of a specific industry rather than achieving general sustainability objectives. In addition, integrating strategic, tactical, and operational decision levels in the design of supply chain networks is critical for evaluating their impact on each other in terms of sustainability. More sophisticated mathematical solution methods for dealing with real-life scenarios including nonlinearity and uncertainty sources are required. The paper concludes with new prospects of research to promote a better integration of sustainability into supply chain networks.

Fine-grained effect sizes.

To make transparent individuals' responses to intervention over time in the systematic review of single-case experimental designs, we developed a method of estimating and graphing fine-grained effect sizes. Fine-grained effect sizes are both case- and time-specific and thus provide more nuanced information than effect size estimates that average effects across time, across cases, or both. We demonstrate the method for estimating fine-grained effect sizes under three different baseline stability assumptions: outcome stability, level stability, and trend stability. We then use the method to graph individual effect trajectories from three single-case experimental design studies that examined the impact of self-management interventions on students identified with autism. We conclude by discussing limitations associated with estimating and graphing fine-grained effect sizes and directions for further development. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

In-vehicle displays for driving automation: a scoping review of display design and evaluation using driver gaze measures

ABSTRACT Recent research has extensively examined in-vehicle display designs for supporting the operation of driving automation. As automation relieves drivers from various driving tasks including vehicle control (e.g. steering, accelerating, and braking), driving performance measures (e.g. speed, lane deviations) may not be informative indicators for evaluating the effectiveness of in-vehicle displays. Gaze-based measures are a better alternative given their link to driver visual attention, an indication of driver engagement. A scoping review was conducted to review the literature on the design of displays for supporting the operation of driving automation and the evaluation of these displays using gaze-based measures. Forty-three articles were included in the review. Most of the studies investigated visual (and mixed visual-auditory) displays that provide alerts to the driver for when to intervene automation classified as Level 3. The adopted gaze measures mostly relied on static areas of interest (AOIs), with fewer studies looking at more fine-grained, context dependent AOIs. The paper summarises the findings of the review, including research trends and gaps, as well as recommendations for future research.

A Regulatory Perspective: Have We Done Enough on Grasping Automation Failure?

This paper responds to Skraaning and Jamieson’s target paper “The Failure to Grasp Automation Failure.” We acknowledge that the target paper made important contributions to automation research in the human factors community. It analyzed automation failure events in complex operational systems in contrast to the vast majority of laboratory research on human-automation interaction. The paper presented a taxonomy of automation failure. The analysis and taxonomy demonstrate the integration of approaches to grasping automation failures from system instrumentation and controls, human factors engineering, and human reliability analysis. We reviewed the regulatory framework related to use of automation in nuclear power plants and examined whether the framework elements adequately address “Failure to Grasp Automation Failure” using the taxonomy in the target paper. Overall, we believe that the target paper could enhance the consideration for potential automation failures in the design and regulatory review process of automation technologies.

Common challenges and suggestions for risk of bias tool development: a systematic review of methodological studies

ObjectiveTo review the findings of studies that have evaluated the design and/or usability of key risk of bias (RoB) tools for the assessment of RoB in primary studies, as categorised by the LATITUDES Network (a searchable library of RoB tools for evidence synthesis): PROBAST, RoB2, ROBINS-I, QUADAS-2, QUADAS-C, QUAPAS, ROBINS-E, and the COSMIN RoB checklist. Study design and settingSystematic review of methodological studies. We conducted a forward citation search from the primary report of each tool, to identify primary studies aiming to evaluate the design and/or usability of the tool. Two reviewers assessed studies for inclusion. We extracted tool features into Microsoft Word and used NVivo for document analysis, comprising a mix of deductive and inductive approaches. We summarised findings within each tool and explored common findings across tools. ResultsWe identified 13 tool evaluations meeting our inclusion criteria: PROBAST (3); RoB2 (3); ROBINS-I (4); QUADAS-2 (3). We identified no evaluations for the other tools. Evaluations varied in clinical topic area, methodology, approach to bias assessment and tool user background. Some had limitations affecting generalisability. We identified common findings across tools for 6/14 themes: 1) challenging items (e.g. RoB2/ROBINS-I “deviations from intended interventions” domain), 2) overall RoB judgement (concerns with overall risk calculation in PROBAST/ROBINS-I), 3) tool usability (concerns about complexity), 4) time to complete tool (varying demands on time e.g. depending on number of outcomes assessed), 5) user agreement (varied across tools), and 6) recommendations for future use (e.g. piloting) and development (add intermediate domain answer to QUADAS-2/PROBAST; provide clearer guidance for all tools). Of the other eight themes, seven only had findings for the QUADAS-2 tool, limiting comparison across tools, and one (“re-organisation of questions”) had no findings. ConclusionEvaluations of key RoB tools have posited common challenges and recommendations for tool use and development. These findings may be helpful to people using or developing RoB tools. Guidance is necessary to support the design and implementation of future RoB tool evaluations.

An Architectural Solution to a Biological Problem: A Systematic Review of Lighting Designs in Healthcare Environments

Neuroscience and biological evidence emphasizes the profound influence of natural light on human health, offering benefits such as reducing fatigue, heightened alertness in healthcare providers, and improving patient outcomes. The objective of this review is to identify scientific studies and research to evaluate and report evidence of indoor lighting conditions’ influence on health outcomes, which can be used to develop lighting designs that align circadian rhythms in healthcare settings. A comprehensive search was conducted to identify rigorous empirical studies focused on the link between interior lighting conditions with health outcomes in the healthcare environment. For a comprehensive review of the existing literature, a four-phased methodology was employed including literature search, screening, and selection. Literature appraisals were conducted to determine the relevance and quality of evidence for each study identified. In addition, using a thematic analysis, patterns were identified, analyzed, and interpreted within the literature review. Accordingly, the results were organized into two main groups interventional human subjects and simulation-based studies. Despite evidence that natural light influences human health and happiness, a synthesis of reviewed studies suggests that the evidence for the benefits of artificial lighting in healthcare settings is less conclusive, with potential factors including variations in lighting design, inconsistent implementation of lighting interventions, and differing sample populations across studies. We conclude with an executive summary suggesting that future research should use standardized metrics and methods to focus on bridging the gap between theoretical understanding and practical application in lighting design for healthcare environments. Collaboration among architects, designers, lighting experts, and healthcare professionals can address these factors contributing to building a stronger evidence-based design for the benefits of artificial lighting in healthcare settings.

A comprehensive review of energy-efficient design in satellite communication systems

Satellite communication systems play a pivotal role in enabling global connectivity, but their energy consumption presents significant challenges in terms of sustainability and operational costs. This comprehensive review explores various aspects of energy-efficient design in satellite communication systems to address these challenges. Beginning with an overview of the fundamentals of energy efficiency in satellite communications, including key metrics and parameters, the review delves into the analysis of energy consumption across different subsystems. Strategies for optimizing energy efficiency in transmission protocols, modulation schemes, power management, and control are examined, along with case studies showcasing successful implementations. Emerging technologies and trends in satellite communication are explored for their potential to enhance energy efficiency. Regulatory and environmental considerations are also discussed, emphasizing the importance of aligning energy-efficient design with regulatory frameworks and addressing environmental impacts. Ultimately, this review highlights the importance of prioritizing energy efficiency in satellite communication system design to mitigate environmental impact, reduce operational costs, and ensure sustainability in an increasingly interconnected world.

A Development in Solar Desalination System with Flashing of Solar Heated Water

Solar still was successfully used for the desalination of saline water in many arid and oceanic regions of the world. But the yield of solar still was found very low and fluctuating. The new develop system with the flashing of solarheated water is found possible during the study of flashing of hot water in many thermal processes used during the chemical and pharmaceutical processes. A compact and effective desalination system using solar energy had designed during the research work from the design reviews collected from flashing hot water devices used in many thermal processes. The compact flash chamber and flash steam condenser are critical components developed for the novel desalination system using locally available materials during the research work. In present experimental work a flash chamber is designed for flashing of solar heated water. Experimental work shows that by increasing the mass flow rate of water from 0.01 kg/sec to 0.02 kg/sec the distillate output of water could be increased with higher temperature of water. It shows that around 38% of higher distillate output in water could be achieved with development of new system.

From risk study to field evidence: an unprecedented and isolated case of DEF in Brazil

This paper presents the first case ever reported in Brazil where delayed ettringite formation (DEF) has been confirmed as the sole cause of deterioration in field concrete. Still under construction and with less than 2 years of age, numerous cracks were observed in the foundation structures of a building located in Recife, a city known for its history of alkali-aggregate reaction (AAR) cases. In addition to the field survey of cracks, microstructural analyses, residual expansion, compressive strength, review of structural design, the determination of the sulfates content in the groundwater and simplified thermal analysis were carried out. Results confirmed that the DEF was the isolated cause of the damages present in those cast-in-place concrete structures, with no evidence of AAR or any other deterioration process. This work corroborates studies previously published on the high risk of the occurrence of DEF in the region, demonstrating the urgent need for a preventive technical standard in the country, considering the chemical composition of cements and mainly prior thermal analyzes to adopt possible preventive measures to limit the maximum internal temperature of the concrete.

Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project

Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive variants was developed in the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, but the known indels in the known-positive set were limited. This project sought to provide an enriched set of known indels that would be more translationally relevant by focusing on additional cancer related regions. A thorough manual review process completed by 42 reviewers, two advisors, and a judging panel of three researchers significantly enriched the known indel set by an additional 516 indels. The extended benchmarking indel set has a large range of variant allele frequencies (VAFs), with 87% of them having a VAF below 20% in reference Sample A. The reference Sample A and the indel set can be used for comprehensive benchmarking of indel calling across a wider range of VAF values in the lower range. Indel length was also variable, but the majority were under 10 base pairs (bps). Most of the indels were within coding regions, with the remainder in the gene regulatory regions. Although high confidence can be derived from the robust study design and meticulous human review, this extensive indel set has not undergone orthogonal validation. The extended benchmarking indel set, along with the indels in the previously published known-positive set, was the truth set used to benchmark indel calling pipelines in a community challenge hosted on the precisionFDA platform. This benchmarking indel set and reference samples can be utilized for a comprehensive evaluation of indel calling pipelines. Additionally, the insights and solutions obtained during the manual review process can aid in improving the performance of these pipelines.